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Quantitative Proteome Profiling of Coxiella burnetii Reveals Major Metabolic and Stress Differences Under Axenic and Cell Culture Cultivation

Dresler, Jiri; Klimentova, Jana; Pajer, Petr; Salovska, Barbora; Myslivcová Fučíková, Alena; Chmel, Martin; Schmoock, Gernot; Neubauer, Heinrich; Mertens-Scholz, Katja (Frontiers media, 2019)

Coxiella burnetii is the causative agent of the zoonotic disease Q fever. To date, the lipopolysaccharide (LPS) is the only defined and characterized virulence determinant of C. burnetii. In this study, proteome profiles ...
The Evaluation of Glioblastoma Cell Dissociation and Its Influence on Its Behavior

Skarkova, Veronika; Krupova, Marketa; Vitovcova, Barbora; Skarka, Adam; Kasparova, Petra; Krupa, Petr; Kralova, Vera; Rudolf, Emil (MDPI, 2019)

Purpose: Primary cell lines are a valuable tool for evaluation of tumor behavior or sensitivity to anticancer treatment and appropriate dissociation of cells could preserve genomic profile of the original tissue. The main ...
Novel Benzothiazole-Based Ureas as 17 beta-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment

Aitken, Laura; Benek, Ondřej; McKelvie, Brogan E.; Hughes, Rebecca E.; Hroch, Lukas; Schmidt, Monika; Major, Louise L.; Vinklářová, Lucie; Kuča, Kamil; Smith, Terry K.; Musílek, Kamil; Gunn-Moore, Frank J. (MDPI-Molecular diversity preservation international, 2019)

It has long been established that mitochondrial dysfunction in Alzheimer's disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17 ...
Changes in Content of Polyphenols and Ascorbic Acid in Leaves of White Cabbage after Pest Infestation

Kovalíková, Zuzana; Kubes, Jan; Skalický, Milan; Kuchtíčková, Nikola; Mašková, Lucie; Tůma, Jiří; Vachova, Pavla; Hejnák, Vaclav (MDPI-Molecular diversity preservation international, 2019)

Crops, such as white cabbage (Brassica oleracea L. var. capitata (L.) f. alba), are often infested by herbivorous insects that consume the leaves directly or lay eggs with subsequent injury by caterpillars. The plants can ...
Methods for the Evaluation of the Stochastic Properties of the Ionosphere for Earthquake Prediction—Random Matrix Theory

Břízová, Leontýna; Kříž, Jan; Studnička, Filip; Šlégr, Jan (MDPI-Molecular diversity preservation international, 2019)

Seismo-ionospheric coupling is a field of great interest and is currently subject to rigorous study; using both ground and satellite data and many phenomenological features, the ionospheric precursors of earthquakes were ...
On Diophantine equations involving Lucas sequences

Trojovský, Pavel (De Gruyter, 2019)

In this paper, we study the Diophantine equation $u_n=R(m)P(m)^{Q(m)}$,where $R, P$ and $Q$ are some polynomials (under weak assumptions) and $u_n$ is a Lucas sequence, thus the sequence $(u_n)_{n\geq 0}$ with characteristic ...
On Terms of Generalized Fibonacci Sequences which are Powers of their Indexes

Trojovský, Pavel (MDPI-Molecular diversity preservation international, 2019)

The k-generalized Fibonacci sequence (Fn(k))n (sometimes also called k-bonacci or k-step Fibonacci sequence), with k >= 2, is defined by the values 0,0, horizontal ellipsis ,0,1 of starting k its terms and such way that ...
Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions

Kubicek, Vladimir; Skalova, Lenka; Skarka, Adam; Kralova, Vera; Holubova, Jana; Stepankova, Jana; Subrt, Zdenek; Szotakova, Barbora (FRONTIERS MEDIA SA, 2019)

Flubendazole (FLU), an anthelmintic drug of benzimidazole type, is now considered a promising anti-cancer agent due to its tubulin binding ability and low system toxicity. The present study was aimed at determining more ...
Algebraic numbers as product of powers of transcendental numbers

Trojovský, Pavel (MDPI-Molecular diversity preservation international, 2019)

The elementary symmetric functions played a crucial role in the study of zeros of non-zero polynomials in $C[x]$, and the problem of finding zeros in $Q[x]$ leads to the definition of algebraic and transcendental numbers. ...
Space, Habitat and Isolation are the Key Determinants of Tree Colonization by the Carpenter Ant in Plantation Forests

Véle, Adam; Horák, Jakub (MDPI-Molecular diversity preservation international, 2019)

Forest plantations are still often considered the antithesis of real nature. However, plantations can host many organisms. The problem is that some of the hosted species are regarded ad hoc as pests. The main aim of our ...
Arbuscular Mycorrhiza Improves Leaf Food Quality of Tea Plants

Shao, Ya-Dong; Zhang, De-Jian; Hu, Xian-Chun; Wu, Qiang-Sheng; Jiang, Chang-Jun; Gao, Xiu-Bing; Kuča, Kamil (Universitatea de Stiinte Agricole si Medicina Veterinara, 2019)

Tea (Camellia sinensis) plants inhabit arbuscular mycorrhizal fungi (AMF) in rhizosphere, whereas it is not clear whether AMF improves leaf food quality of tea plants. A potted study was conducted to determine effects of ...
3D technology in the cultural heritage and education context

Milková, Eva; Maněnová, Martina; Chadimová, Lenka; Ntalianis, Klimis (North atlantic university union, 2019)

Modern technologies are getting involved in most spheres of human activities, they play an important role also in cultural heritage care. These technologies are used when research into historical reference is carried out, ...
Low-Cost Radon Detector with Low-Voltage Air-Ionization Chamber

Studnička, Filip; Štěpán, Jan; Šlégr, Jan (MDPI-Molecular diversity preservation international, 2019)

This paper describes the design of a low-cost radon detector that can easily be fabricated in large quantities for the purposes of earthquake prediction. The described detector can also be used for monitoring radon levels ...
Integrative rDNAomics—Importance of the Oldest Repetitive Fraction of the Eukaryote Genome

Symonová, Radka (MDPI, 2019)

Nuclear ribosomal RNA (rRNA) genes represent the oldest repetitive fraction universal to all eukaryotic genomes. Their deeply anchored universality and omnipresence during eukaryotic evolution reflects in multiple roles ...
Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease

Brum, Juliana de Oliveira C.; Neto, Denise Cristian F.; de Almeida, Joyce Sobreiro E. D.; Lima, Joselia Alencar; Kuča, Kamil; Costa Franca, Tanos Celmar; Figueroa-Villar, Jose D. (MDPI-Molecular diversity preservation international, 2019)

Six quinoline-piperonal hybrids were synthesized and evaluated as potential drugs against Alzheimer's disease (AD). Theoretical analysis of the pharmacokinetic and toxicological properties of the compounds suggest that ...
On the Sum of Reciprocal of Polynomial Applied to Higher Order Recurrences

Trojovský, Pavel (MDPI-Molecular diversity preservation international, 2019)

Recently a lot of papers were devoted to partial infinite reciprocal sums of a higher-order linear recursive sequence. In this paper, we continue this program by finding a sequence which is asymptotically equivalent to ...
Biodiversity in remnants of natural mountain forests under conservation-oriented management

Horák, Jakub; Materna, Jan; Halda, Josef; Mladenovic, Strahinja; Bogusch, Petr; Pech, Pavel (Nature Publishing Group, 2019)

The structure of forests is an important stabilizing factor regarding ongoing global climate and land use change. Biodiverse mountain forests with natural structure are one of the ecosystems most endangered by these problems. ...
Experimental Verification of Effectiveness of English Language Teaching Using MyEnglishLab

Vymetálková, Danuše; Milková, Eva (MDPI-Molecular diversity preservation international, 2019)

The paper deals with a research focused on the blended learning model represented by an online component MyEnglishLab complementing English paper-based materials. At first, we viewed the blended learning model and we ...
Nucleotide composition of transposable elements likely contributes to AT/GC compositional homogeneity of teleost fish genomes

Symonová, Radka; Suh, Alexander (BMC, 2019)

Background: Teleost fish genome size has been repeatedly demonstrated to positively correlate with the proportion of transposable elements (TEs). This finding might have far-reaching implications for our understanding of ...
Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes

Jacevic, Vesna Milovan; Nepovimová, Eugenie; Kuča, Kamil (NATURE PUBLISHING GROUP, 2019)

Certain AChE reactivators, asoxime, obidoxime, K027, K048, and K075, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the different organs. As a continuation of previously ...

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