DSpace Repository

Browsing Přírodovědecká fakulta by Title

Browsing Přírodovědecká fakulta by Title

Sort by: Order: Results:

  • 1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy 
    Kapron, Barbara; Czarnomysy, Robert; Wysokinski, Mariusz; Andrýs, Rudolf; Musílek, Kamil; Angeli, Andrea; Supuran, Claudiu T; Plech, Tomasz (Taylor & Francis, 2020)
    There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results ...
  • 3D technology in the cultural heritage and education context 
    Milková, Eva; Maněnová, Martina; Chadimová, Lenka; Ntalianis, Klimis (North atlantic university union, 2019)
    Modern technologies are getting involved in most spheres of human activities, they play an important role also in cultural heritage care. These technologies are used when research into historical reference is carried out, ...
  • 7-Amino-3-phenyl-2-methyl-pyrazolopyrimidine derivatives inhibit human rhinovirus replication 
    Chakrasali, Prashant; Hwang, Dasom; Lee, Joo-Youn; Jung, Eunhye; Lee, Hye Lim; Reneesh, Alba; Skarka, Adam; Musílek, Kamil; Nguyen, Nhung Hong; Shin, Jin Soo; Jung, Young-Sik (Elsevier, 2024)
    Small molecules that exhibit broad-spectrum enteroviral inhibitory activity by targeting viral replication proteins are highly desired in antiviral drug discovery studies. To discover new human rhinovirus (hRV) inhibitors, ...
  • A-series agent A-234: initial in vitro and in vivo characterization 
    Hrabinova, Martina; Pejchal, Jaroslav; Hepnarova, Vendula; Muckova, Lubica; Junova, Lucie; Opravil, Jakub; Zdarova Karasova, Jana; Rozsypal, Tomas; Dlabkova, Alzbeta; Rehulkova, Helena; Kucera, Tomas; Vecera, Zbynek; Caisberger, Filip; Schmidt, Monika; Soukup, Ondrej; Jun, Daniel (Springer, 2024)
    A-series agent A-234 belongs to a new generation of nerve agents. The poisoning of a former Russian spy Sergei Skripal and his daughter in Salisbury, England, in March 2018 led to the inclusion of A-234 and other A-series ...
  • Acai (Euterpe oleracea Mart.) Seed Oil Exerts a Cytotoxic Role over Colorectal Cancer Cells: Insights of Annexin A2 Regulation and Molecular Modeling 
    da Silva, M.A.C.N.; Tessmann, J.W.; Borges, K.R.A.; Wolff, L.A.S.; Botelho, F.D.; Vieira, L.A.; Morgado-Diaz, J.A.; Costa Franca, Tanos Celmar; Barbosa, M.D.C.L.; Nascimento, M.D.D.S.B.; Rocha, M.R.; de Carvalho, J.E. (Multidisciplinary Digital Publishing Institute (MDPI), 2023)
    Açaí, Euterpe oleracea Mart., is a native plant from the Amazonian and is rich in several phytochemicals with anti-tumor activities. The aim was to analyze the effects of açaí seed oil on colorectal adenocarcinoma (ADC) ...
  • Accelerating AdS black holes in gravity's rainbow 
    Panah, B. Eslam; Zare, Soroush; Hassanabadi, Hassan (SPRINGER, 2024)
    Motivated by the effect of the energy of moving particles in C-metric, we first obtain exact accelerating black hole solutions in gravity's rainbow. Then, we study the effects of gravity's rainbow and C-metric parameters ...
  • Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy 
    Bautista-Aguilera, Óscar M.; Ismaili, Lhassane; Chioua, Mourad; Andrýs, Rudolf; Schmidt, Monika; Bzonek, Petr; Ángeles Martínez-Grau, María; Beadle, Christopher D.; Vetman, Tatiana; López-Muñoz, Francisco; Iriepa, Isabel; Refouvelet, Bernard; Musílek, Kamil; Marco-Contelles, José (MDPI-Molecular diversity preservation international, 2020)
    In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules ...
  • Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention 
    Cavalcante, Samir; Simas, Alessandro B. C; Barcellos, Marcos C; de Oliveira, Victor G. M; Sousa, Roberto B; Cabral, Paulo A. de M; Kuča, Kamil; Costa Franca, Tanos Celmar (MDPI, 2020)
    This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer's ...
  • Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes 
    Jacevic, Vesna Milovan; Nepovimová, Eugenie; Kuča, Kamil (NATURE PUBLISHING GROUP, 2019)
    Certain AChE reactivators, asoxime, obidoxime, K027, K048, and K075, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the different organs. As a continuation of previously ...
  • Adaption of Norway spruce and European beech forests under climate change: from resistance to close-to-nature silviculture 
    Vacek, Zdenek; Vacek, Stanislav; Slanar, Jiri; Bilek, Lukas; Bulusek, Daniel; Stefancik, Igor; Králíček, Ivo; Vancura, Karel (De Gruyter, 2019)
    In time of climate change, close-to-nature silviculture is growing in importance as a tool for future forest management. The paper study the tree layer and natural regeneration of monospecific Norway spruce (Picea abies ...
  • Adaptive Pricing-Based Optimized Resource Utilization in Networked Microgrids 
    Ahsan, Syed Muhammad; Iqbal, Muhammad Ahmad; Hussain, Akhtar; Musílek, Petr (IEEE, 2025)
    The performance of networked microgrids primarily depends on the design of internal market structure for maximum resource utilization, optimized power sharing, and enhanced economic efficiency. This article presents a novel ...
  • Addressing feature selection and extreme learning machine tuning by diversity-oriented social network search: an application for phishing websites detection 
    Bacanin, Nebojsa; Zivkovic, Miodrag; Antonijevic, Milos; Kandasamy, Venkatachalam; Lee, Jinseok; Nam, Yunyoung; Marjanovic, Marina; Strumberger, Ivana; Abouhawwash, Mohamed (SPRINGER HEIDELBERG, 2023)
    Feature selection and hyper-parameters optimization (tuning) are two of the most important and challenging tasks in machine learning. To achieve satisfying performance, every machine learning model has to be adjusted for ...
  • Advancements in High-Performance Computing in Early Diagnosis of Alzheimer's Disease: A Systematic Review 
    Kirimtat, Ayca; Krejcar, Ondřej; Marešová, Petra; Selamat, Ali Bin; Kuča, Kamil (IEEE, 2024)
    Background: The key histopathological features of Alzheimer's disease (AD) include extensive brain shrinkage and amyloid plaques made up of amyloid beta (Aβ) deposition, as well as neurofibrillary tangles (NFTs) made up ...
  • Advances in the concept of functional foods and feeds: applications of cinnamon and turmeric as functional enrichment ingredients 
    Kumar, Harsh; Dhalaria, R.; Guleria, S.; Sharma, R.; Cimler, Richard; Dhanjal, D.S.; Chopra, C.; Kumar, V.; Manickam, S.; Siddiqui, S.A.; Kaur, T.; Verma, N.; Kumar Pathera, A.; Kuča, Kamil (Taylor & Francis, 2025)
    Spices are a rich source of vitamins, polyphenols, proteins, dietary fiber, and minerals such as calcium, magnesium, iron, and zinc, all of which play an important role in biological functions. Since ancient times, spices ...
  • Advances in Vertebrate (Cyto)Genomics Shed New Light on Fish Compositional Genome Evolution 
    Matoulek, Dominik; Ježek, Bruno; Vohnoutova, Marta; Symonova, Radka (MDPI, 2023)
    Cytogenetic and compositional studies considered fish genomes rather poor in guanine-cytosine content (GC%) because of a putative "sharp increase in genic GC% during the evolution of higher vertebrates". However, the ...
  • Aflatoxin Detoxification Using Microorganisms and Enzymes 
    Guan, Y.; Chen, J.; Nepovimová, Eugenie; Long, M.; Wu, Wenda; Kuča, Kamil (MDPI-Molecular diversity preservation international, 2021)
    Mycotoxin contamination causes significant economic loss to food and feed industries and seriously threatens human health. Aflatoxins (AFs) are one of the most harmful mycotoxins, which are produced by Aspergillus flavus, ...
  • Aflatoxins: History, Significant Milestones, Recent Data on Their Toxicity and Ways to Mitigation 
    Picková, Darina; Ostrý, Vladimír; Toman, Jakub; Malíř, František (MDPI-Molecular diversity preservation international, 2021)
    In the early 1960s the discovery of aflatoxins began when a total of 100,000 turkey poults died by hitherto unknown turkey "X" disease in England. The disease was associated with Brazilian groundnut meal affected by ...
  • Age-associated changes in innate and adaptive immunity: role of the gut microbiota 
    Gao, Haoyu; Nepovimová, Eugenie; Adam, Vojtech; Heger, Zbynek; Valko, Marian; Wu, Qinghua; Kuča, Kamil (Frontiers media, 2024)
    Aging is generally regarded as an irreversible process, and its intricate relationship with the immune system has garnered significant attention due to its profound implications for the health and well-being of the aging ...
  • Age-based analysis of the brain activity during sleep induced by medication 
    Pakniyat, Najmeh; Vivekanandhan, Gayathri; Rajagopal, Karthikeyan; Krejcar, Ondřej; Kuča, Kamil; Namazi, Hamidreza (World scientific, 2023)
    One of the important areas of research in neuroscience is to investigate how brain activity changes during aging. In this research, we employ complexity techniques to analyze how brain activity changes based on the age of ...
  • Agroinfiltration mediated scalable transient gene expression in genome edited crop plants 
    Kaur, M.; Manchanda, P.; Kalia, A.; Ahmed, F.K.; Nepovimová, Eugenie; Kuča, Kamil; Abd-Elsalam, K.A. (MDPI, 2021)
    Agrobacterium-mediated transformation is one of the most commonly used genetic transformation method that involves transfer of foreign genes into target plants. Agroinfiltration, an Agrobacterium-based transient approach ...

Search DSpace


Browse

My Account