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Browsing Přírodovědecká fakulta by Author "Benek, Ondřej"

Browsing Přírodovědecká fakulta by Author "Benek, Ondřej"

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  • Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17 beta-HSD10 with Implications to Alzheimer's Disease Treatment 
    Schmidt, Monika; Benek, Ondřej; Vinklářová, Lucie; Hrabinova, Martina; Zemanová, Lucie; Chribek, Matej; Kralova, Vendula; Hroch, Lukas; Doležal, Rafael; Lyčka, Antonín; Prchal, Lukas; Jun, Daniel; Aitken, Laura; Gunn-Moore, Frank; Kuča, Kamil; Musílek, Kamil (MDPI-Molecular diversity preservation international, 2020)
    Human 17 beta-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological ...
  • Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation 
    Benek, Ondřej; Vašková, Michaela; Sedláček Miškeříková, Markéta; Schmidt, Monika; Andrýs, Rudolf; Rotterová, Aneta; Skarka, Adam; Hatlapatkova, Jana; Karasova, Jana Zdarova; Medvecký, Matej; Hroch, Lukas; Vinklářová, Lucie; Fisar, Zdenek; Hroudova, Jana; Handl, Jiri; Capek, Jan; Rousar, Tomas; Kobrlova, Tereza; Dolezal, Rafael; Soukup, Ondrej; Aitken, Laura; Gunn-Moore, Frank; Musílek, Kamil (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2023)
    17 beta-hydroxysteroid dehydrogenase type 10 (17 beta-HSD10) is a multifunctional mitochondrial enzyme and putative drug target for the treatment of various pathologies including Alzheimer's disease or some types of ...
  • Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors 
    Skok, Ziga; Barancokova, Michaela; Benek, Ondřej; Cruz, Cristina Durante; Tammela, Paivi; Tomasic, Tihomir; Zidar, Nace; Masic, Lucija Peterlin; Zega, Anamarija; Stevenson, Clare E. M; Mundy, Julia E. A; Lawson, David M; Maxwell, Anthony; Kikelj, Danijel; Ilas, Janez (American chemical society, 2020)
    We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve the ...
  • Friend or enemy? Review of 17 beta-HSD10 and its role in human health or disease 
    Vinklářová, Lucie; Schmidt, Monika; Benek, Ondřej; Kuča, Kamil; Gunn-Moore, Frank; Musílek, Kamil (WILEY, 2020)
    17 beta-hydroxysteroid dehydrogenase (17 beta-HSD10) is a multifunctional human enzyme with important roles both as a structural component and also as a catalyst of many metabolic pathways. This mitochondrial enzyme has ...
  • New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease 
    Houfková, Aneta; Schmidt, Monika; Benek, Ondřej; Fabrik, Ivo; Andrýs, Rudolf; Zemanová, Lucie; Soukup, Ondrej; Musílek, Kamil (Biomed central, 2025)
    Background The mitochondrial enzyme 17 beta-hydroxysteroid dehydrogenase type 10 (HSD10) is implicated in neurodegenerative disorders, particularly Alzheimer's disease (AD), through its interplay with the amyloid-beta ...
  • Novel Benzothiazole-Based Ureas as 17 beta-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment 
    Aitken, Laura; Benek, Ondřej; McKelvie, Brogan E.; Hughes, Rebecca E.; Hroch, Lukas; Schmidt, Monika; Major, Louise L.; Vinklářová, Lucie; Kuča, Kamil; Smith, Terry K.; Musílek, Kamil; Gunn-Moore, Frank J. (MDPI-Molecular diversity preservation international, 2019)
    It has long been established that mitochondrial dysfunction in Alzheimer's disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17 ...

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