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Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes

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dc.rights.license CC BY eng
dc.contributor.author Jacevic, Vesna Milovan cze
dc.contributor.author Nepovimová, Eugenie cze
dc.contributor.author Kuča, Kamil cze
dc.date.accessioned 2020-06-07T20:51:29Z
dc.date.available 2020-06-07T20:51:29Z
dc.date.issued 2019 eng
dc.identifier.issn 2045-2322 eng
dc.identifier.uri http://hdl.handle.net/20.500.12603/337
dc.description.abstract Certain AChE reactivators, asoxime, obidoxime, K027, K048, and K075, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the different organs. As a continuation of previously published data, in this study, Wistar rats have sacrificed 24 hrs and 7 days after single im application of 0.1LD(50), 0.5LD(50) and 1.0LD(50) of each reactivator, and examinated tissue samples were obtained for pathohistological and semiquantitative analysis. A severity of tissue alteration, expressed as different tissue damage scores were evaluated. Morphological structure of examinated tissues treated with of 0.1LD(50) of all reactivators was comparable with the control group of rats. Moderate injuries were seen in visceral tissues treated with 0.5LD(50) of asoxime, obidoxime and K027. Acute damages were enlarged after treatment with 0.5LD(50) and 1.0LD(50) of all reactivators during the next 7 days. The most prominent changes were seen in rats treated with 1.0LD(50) of K048 and K075 (P < 0.001 vs. control and asoxime-treated group). All reactivators given by a single, high, unitary dose regimen, have an adverse effect not only on the main visceral tissue, but on the whole rat as well, but the exact mechanism of cellular injury remains to be confirmed in further investigation. eng
dc.format p. &quot;Article Number: 16425&quot; eng
dc.language.iso eng eng
dc.publisher NATURE PUBLISHING GROUP eng
dc.relation.ispartof Scientific reports, volume 9, issue: November eng
dc.subject endoplasmic-reticulum stress eng
dc.subject acetylcholinesterase reactivators eng
dc.subject pyridinium oximes eng
dc.subject fullerenol nanoparticles eng
dc.subject nerve agents eng
dc.subject in-vitro eng
dc.subject organophosphorus eng
dc.subject sarin eng
dc.subject countermeasures eng
dc.subject induction eng
dc.subject stres endoplazmatického retikula cze
dc.subject reaktivátory acetylcholinesterázy cze
dc.subject pyridinium oximy cze
dc.subject fullerenolové nanočástice cze
dc.subject nervové látky cze
dc.subject in-vitro cze
dc.subject organofosfor cze
dc.subject sarin cze
dc.subject protiopatření cze
dc.subject indukce cze
dc.title Acute Toxic Injuries of Rat's Visceral Tissues Induced by Different Oximes eng
dc.title.alternative Akutní toxická poranění krysích viscerálních tkání vyvolaných různými oximy cze
dc.type article eng
dc.identifier.obd 43875719 eng
dc.identifier.wos 000495611100017 eng
dc.identifier.doi 10.1038/s41598-019-52768-4 eng
dc.description.abstract-translated Certain AChE reactivators, asoxime, obidoxime, K027, K048, and K075, when taken in overdoses and sometimes even when introduced within therapeutic ranges, may injure the different organs. As a continuation of previously published data, in this study, Wistar rats have sacrificed 24 hrs and 7 days after single im application of 0.1LD(50), 0.5LD(50) and 1.0LD(50) of each reactivator, and examinated tissue samples were obtained for pathohistological and semiquantitative analysis. A severity of tissue alteration, expressed as different tissue damage scores were evaluated. Morphological structure of examinated tissues treated with of 0.1LD(50) of all reactivators was comparable with the control group of rats. Moderate injuries were seen in visceral tissues treated with 0.5LD(50) of asoxime, obidoxime and K027. Acute damages were enlarged after treatment with 0.5LD(50) and 1.0LD(50) of all reactivators during the next 7 days. The most prominent changes were seen in rats treated with 1.0LD(50) of K048 and K075 (P < 0.001 vs. control and asoxime-treated group). All reactivators given by a single, high, unitary dose regimen, have an adverse effect not only on the main visceral tissue, but on the whole rat as well, but the exact mechanism of cellular injury remains to be confirmed in further investigation. cze
dc.publicationstatus postprint eng
dc.peerreviewed yes eng
dc.source.url https://www.nature.com/articles/s41598-019-52768-4 cze
dc.relation.publisherversion https://www.nature.com/articles/s41598-019-52768-4 eng
dc.rights.access Open Access eng


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