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Integrative rDNAomics—Importance of the Oldest Repetitive Fraction of the Eukaryote Genome

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dc.rights.license CC BY eng
dc.contributor.author Symonová, Radka cze
dc.date.accessioned 2020-06-07T20:39:05Z
dc.date.available 2020-06-07T20:39:05Z
dc.date.issued 2019 eng
dc.identifier.issn 2073-4425 eng
dc.identifier.uri http://hdl.handle.net/20.500.12603/320
dc.description.abstract Nuclear ribosomal RNA (rRNA) genes represent the oldest repetitive fraction universal to all eukaryotic genomes. Their deeply anchored universality and omnipresence during eukaryotic evolution reflects in multiple roles and functions reaching far beyond ribosomal synthesis. Merely the copy number of non-transcribed rRNA genes is involved in mechanisms governing e.g. maintenance of genome integrity and control of cellular aging. Their copy number can vary in response to environmental cues, in cellular stress sensing, in development of cancer and other diseases. While reaching hundreds of copies in humans, there are records of up to 20,000 copies in fish and frogs and even 400,000 copies in ciliates forming thus a literal subgenome or an rDNAome within the genome. From the compositional and evolutionary dynamics viewpoint, the precursor 45S rDNA represents universally GC-enriched, highly recombining and homogenized regions. Hence, it is not accidental that both rDNA sequence and the corresponding rRNA secondary structure belong to established phylogenetic markers broadly used to infer phylogeny on multiple taxonomical levels including species delimitation. However, these multiple roles of rDNAs have been treated and discussed as being separate and independent from each other. Here, I aim to address nuclear rDNAs in an integrative approach to better assess the complexity of rDNA importance in the evolutionary context. eng
dc.format p. 1-15 eng
dc.language.iso eng eng
dc.publisher MDPI eng
dc.relation.ispartof Genes, volume 10, issue: 5 eng
dc.subject GC-content eng
dc.subject nuclear rDNA eng
dc.subject nucleolus eng
dc.subject rRNA eng
dc.subject secondary structure eng
dc.subject GC-obsah cze
dc.subject jaderná rDNA cze
dc.subject nucleolus cze
dc.subject rRNA cze
dc.subject sekundární struktura cze
dc.title Integrative rDNAomics—Importance of the Oldest Repetitive Fraction of the Eukaryote Genome eng
dc.title.alternative Integrativní rDNAomika-Význam nejstarší repetitivní frakce Eukaryotického Genomu. cze
dc.type article eng
dc.identifier.obd 43875189 eng
dc.identifier.doi 10.3390/genes10050345 eng
dc.description.abstract-translated Nuclear ribosomal RNA (rRNA) genes represent the oldest repetitive fraction universal to all eukaryotic genomes. Their deeply anchored universality and omnipresence during eukaryotic evolution reflects in multiple roles and functions reaching far beyond ribosomal synthesis. Merely the copy number of non-transcribed rRNA genes is involved in mechanisms governing e.g. maintenance of genome integrity and control of cellular aging. Their copy number can vary in response to environmental cues, in cellular stress sensing, in development of cancer and other diseases. While reaching hundreds of copies in humans, there are records of up to 20,000 copies in fish and frogs and even 400,000 copies in ciliates forming thus a literal subgenome or an rDNAome within the genome. From the compositional and evolutionary dynamics viewpoint, the precursor 45S rDNA represents universally GC-enriched, highly recombining and homogenized regions. Hence, it is not accidental that both rDNA sequence and the corresponding rRNA secondary structure belong to established phylogenetic markers broadly used to infer phylogeny on multiple taxonomical levels including species delimitation. However, these multiple roles of rDNAs have been treated and discussed as being separate and independent from each other. Here, I aim to address nuclear rDNAs in an integrative approach to better assess the complexity of rDNA importance in the evolutionary context. cze
dc.publicationstatus postprint eng
dc.peerreviewed yes eng
dc.source.url https://www.mdpi.com/2073-4425/10/5/345/htm cze
dc.relation.publisherversion https://www.mdpi.com/2073-4425/10/5/345/htm eng
dc.rights.access Open Access eng


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