Prohlížení dle předmětu "benzothiazole"

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  • Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17 beta-HSD10 with Implications to Alzheimer's Disease Treatment 
    Schmidt, Monika; Benek, Ondřej; Vinklářová, Lucie; Hrabinova, Martina; Zemanová, Lucie; Chribek, Matej; Kralova, Vendula; Hroch, Lukas; Doležal, Rafael; Lyčka, Antonín; Prchal, Lukas; Jun, Daniel; Aitken, Laura; Gunn-Moore, Frank; Kuča, Kamil; Musílek, Kamil (MDPI-Molecular diversity preservation international, 2020)
    Human 17 beta-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological ...
  • Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors 
    Skok, Ziga; Barancokova, Michaela; Benek, Ondřej; Cruz, Cristina Durante; Tammela, Paivi; Tomasic, Tihomir; Zidar, Nace; Masic, Lucija Peterlin; Zega, Anamarija; Stevenson, Clare E. M; Mundy, Julia E. A; Lawson, David M; Maxwell, Anthony; Kikelj, Danijel; Ilas, Janez (American chemical society, 2020)
    We designed and synthesized a series of inhibitors of the bacterial enzymes DNA gyrase and DNA topoisomerase IV, based on our recently published benzothiazole-based inhibitor bearing an oxalyl moiety. To improve the ...
  • Novel Benzothiazole-Based Ureas as 17 beta-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment 
    Aitken, Laura; Benek, Ondřej; McKelvie, Brogan E.; Hughes, Rebecca E.; Hroch, Lukas; Schmidt, Monika; Major, Louise L.; Vinklářová, Lucie; Kuča, Kamil; Smith, Terry K.; Musílek, Kamil; Gunn-Moore, Frank J. (MDPI-Molecular diversity preservation international, 2019)
    It has long been established that mitochondrial dysfunction in Alzheimer's disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17 ...

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