Prohlížení dle předmětu "Alzheimer’s disease"

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  • Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer’s Disease Therapy 
    Bautista-Aguilera, Óscar M.; Ismaili, Lhassane; Chioua, Mourad; Andrýs, Rudolf; Schmidt, Monika; Bzonek, Petr; Ángeles Martínez-Grau, María; Beadle, Christopher D.; Vetman, Tatiana; López-Muñoz, Francisco; Iriepa, Isabel; Refouvelet, Bernard; Musílek, Kamil; Marco-Contelles, José (MDPI-Molecular diversity preservation international, 2020)
    In this communication, we report the synthesis and cholinesterase (ChE)/monoamine oxidase (MAO) inhibition of 19 quinolinones (QN1-19) and 13 dihydroquinolinones (DQN1-13) designed as potential multitarget small molecules ...
  • Anticipated Social and Healthcare Economic Burden of People with Alzheimer’s Disease in Two Selected Regions of the Czech Republic 
    Marešová, Petra; Komárková, Lenka; Kühnová, Jitka; Cimler, Richard; Pažitný, Peter; Kandilaki, Daniela; Musílek, Kamil; Truhlářová, Zuzana; Zemek, Filip; Kuča, Kamil (MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 2020)
    Increasing life expectancy in modern society is undoubtedly due to improved healthcare, scientific advances in medicine, and the overall healthy lifestyle of the general population. However, this positive trend has led to ...
  • The business process model and notation used for the representation of alzheimer’s disease patients care process 
    Kopecký, Martin; Tomášková, Hana (MDPI AG, 2020)
    Currently, the number of patients with neurological diseases is increasing, especially those older than 65 suffering from Alzheimer’s disease. This development increases the emphasis on understanding and mapping treatment ...
  • Combat military personnel and selective risk factors for the development of dementias-A review 
    Klímová, Blanka; Marešová, Petra; Kuča, Kamil (Bentham Science Publishers, 2019)
    Due to the growth of life expectancies and the increasing number of elderly population all over the world, there is a risk of growth of aging diseases such as dementia. Recent research studies also indicate that there will ...
  • Nonpharmacological intervention therapies for dementia: potential break-even intervention price and savings for selected risk factors in the European healthcare system 
    Marešová, Petra; Režný, Lukáš; Bauer, Petr; Valko, Marian; Kuča, Kamil (Biomed central, 2024)
    Background New effective treatments for dementia are lacking, and early prevention focusing on risk factors of dementia is important. Non-pharmacological intervention therapies aimed at these factors may provide a ...
  • Organic Foods in Diets of Patients with Alzheimer’s Disease 
    Dziuba, Szymon; Ciernak-Emerych, Anna; Klímová, Blanka; Poulová, Petra; Napora, Piotr; Szromba, Sylwia (MDPI-Molecular diversity preservation international, 2020)
    The focus of this study was on the identification and presentation of the interest in organic foods among people who provide care to patients with Alzheimer’s disease.
  • Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition 
    Misiachna, Anna; Svobodova, Barbora; Netolicky, Jakub; Chvojkova, Marketa; Kleteckova, Lenka; Prchal, Lukas; Novak, Martin; Hrabinova, Martina; Kucera, Tomas; Muckova, Lubica; Moravcova, Zuzana; Karasova Zdarova, Jana; Pejchal, Jaroslav; Blažek, Filip; Maliňák, Dávid; Hakenova, Kristina; Krausova Hrcka, Barbora; Kolcheva, Marharyta; Ladislav, Marek; Korabecny, Jan; Pahnke, Jens; Vales, Karel; Horak, Martin; Soukup, Ondrej (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2024)
    Tacrine (THA), a long withdrawn drug, is still a popular scaffold used in medicinal chemistry, mainly for its good reactivity and multi-targeted effect. However, THA-associated hepatotoxicity is still an issue and must be ...
  • Process Cost Management of Alzheimer’s Disease 
    Tomášková, Hana; Kopecký, Martin; Marešová, Petra (MDPI, 2019)
    Summary: Determining the cost of healthcare and social care for patients is a crucial issue for many parties; therefore, both public and private payments play a decisive role in patient care. The article deals with the ...
  • The role of cellular senescence in neurodegenerative diseases 
    Wang, Yating; Kuča, Kamil; You, Li; Nepovimová, Eugenie; Heger, Zbyněk; Valko, Marian; Adam, Vojtěch; Wu, Qinghua; Jomova, Klaudia (Springer, 2024)
    Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer’s disease (AD) and Parkinson’s disease. Different senescent cell populations secrete senescence-associated secretory phenotypes ...

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