Parcourir par auteur "Nachon, Florian"

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  • Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease 
    Panek, Dawid; Pasieka, Anna; Jonczyk, Jakub; Gawlinska, Milena; Zareba, Paula; Siwek, Agata; Wolak, Malgorzata; Mordyl, Barbara; Gluch-Lutwin, Monika; Latacz, Gniewomir; Brazzolotto, Xavier; Chantegreil, Fabien; Nachon, Florian; Zdarova Karasova, Jana; Pejchal, Jaroslav; Mzik, Martin; Sestak, Vit; Prchal, Lukas; Odvarkova, Jitka; Soukup, Ondrej; Korabecny, Jan; Sorf, Ales; Hamšíková, Marie; Zemanová, Lucie; Muckova, Lubica; Vanova, Nela; Dryja, Pola; Salat, Kinga; Höfner, Georg; Wanner, Klaus; Wieckowska, Anna; Malawska, Barbara (WILEY, 2025)
    Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and behavioral and psychological symptoms of dementia (BPSD). Given that cholinergic neurons are predominantly affected in AD, current ...
  • Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors 
    Benetik, Svit Ferjancic; Proj, Matic; Knez, Damijan; Kosak, Urban; Meden, Anze; Krajsek, Katja; Pislar, Anja; Horvat, Selena; Svajger, Urban; Tesic, Natasa; Pulkrabkova, Lenka; Soukup, Ondrej; Skarka, Adam; Andrýs, Rudolf; Brazzolotto, Xavier; Igert, Alexandre; Nachon, Florian; Dias, Jose; Detka, Jan; Gdula-Argasinska, Joanna; Wyska, Elzbieta; Szafarz, Malgorzata; Manik, Aleksandra; Plachtij, Natalia; Musílek, Kamil; Salat, Kinga; Obreza, Ales; Gobec, Stanislav (American chemical society, 2025)
    The currently approved drugs for the treatment of Alzheimer's disease (AD) fail to address its interconnected pathological processes. Inhibition of butyrylcholinesterase (BChE) and p38 alpha mitogen-activated protein kinase ...

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