Listar por tema "acetylcholinesterase"

Mostrando ítems 1-7 de 7

Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602

Furqan, Tiyyaba; Batool, Sidra; Habib, Rabia; Shah, Mamoona; Kalasz, Huba; Darvas, Ferenc; Kuča, Kamil; Nepovimová, Eugenie; Batool, Sajida; Nurulain, Syed M (MDPI, 2020)

The study documented here was aimed to find the molecular interactions of some of the cannabinoid constituents of cannabis with acetylcholinesterase (AChE). Molecular docking and LogP determination were performed to predict ...
In Vitro Evaluation of Neutral Aryloximes as Reactivators for Electrophorus eel Acetylcholinesterase Inhibited by Paraoxon

Kitagawa, Daniel A. S.; Cavalcante, Samir; de Paula, Reuel L.; Rodrigues, Rafael B.; Bernardo, Leandro B.; da Silva, Munique C. J.; da Silva, Thiago N.; dos Santos, Wellington, V; Granjeiro, Jose M.; de Almeida, Joyce S. F. D.; Barcellos, Marcos C.; Correa, Ana Beatriz de A.; Costa Franca, Tanos Celmar; Kuča, Kamil; Simas, Alessandro B. C. (MDPI, 2019)

Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with ...
Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase.

Jonczyk, Jakub; Kukulowicz, Jedrzej; Latka, Kamil; Malawska, Barbara; Jung, Young-Sik; Musílek, Kamil; Bajda, Marek (MDPI-Molecular diversity preservation international, 2021)

Poisoning with organophosphorus compounds used as pesticides or misused as chemical weapons remains a serious threat to human health and life. Their toxic effects result from irreversible blockade of the enzymes ...
Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

Lee, Hyun Myung; Andrýs, Rudolf; Jonczyk, Jakub; Kim, Kyuneun; Vishakantegowda, Avinash G; Maliňák, Dávid; Skarka, Adam; Schmidt, Monika; Vašková, Michaela; Latka, Kamil; Bajda, Marek; Jung, Young-Sik; Malawska, Barbara; Musílek, Kamil (Taylor & Francis, 2021)

The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when ...
Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study

Valle da Silva, Jorge Alberto; Pereira, Ander Francisco; LaPlante, Steven R; Kuča, Kamil; Ramalho, Teodorico Castro; Costa Franca, Tanos Celmar (MDPI, 2020)

In the present work, we performed a complementary quantum mechanical (QM) study to describe the mechanism by which deprotonated pralidoxime (2-PAM) could reactivate human (Homo sapiens sapiens) acetylcholinesterase (HssAChE) ...
Structure-Guided Design of N-Methylpropargylamino- Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease

Svobodova, Barbora; Pulkrabkova, Lenka; Panek, Dawid; Misiachna, Anna; Kolcheva, Marharyta; Andrýs, Rudolf; Handl, Jiri; Capek, Jan; Nyvltova, Pavlina; Rousar, Tomas; Prchal, Lukas; Hepnarova, Vendula; Hrabinova, Martina; Muckova, Lubica; Tosnerova, Daniela; Karabanovich, Galina; Finger, Vladimir; Soukup, Ondrej; Horak, Martin; Korabecny, Jan (MDPI-Molecular diversity preservation international, 2023)

Alzheimer's disease (AD) is a complex disease with an unknown etiology. Available treatments, limited to cholinesterase inhibitors and N-methyl-d-aspartate receptor (NMDAR) antagonists, provide symptomatic relief only. As ...
Synthesis of New Quinoline-Piperonal Hybrids as Potential Drugs against Alzheimer's Disease

Brum, Juliana de Oliveira C.; Neto, Denise Cristian F.; de Almeida, Joyce Sobreiro E. D.; Lima, Joselia Alencar; Kuča, Kamil; Costa Franca, Tanos Celmar; Figueroa-Villar, Jose D. (MDPI-Molecular diversity preservation international, 2019)

Six quinoline-piperonal hybrids were synthesized and evaluated as potential drugs against Alzheimer's disease (AD). Theoretical analysis of the pharmacokinetic and toxicological properties of the compounds suggest that ...

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Listar por tema "acetylcholinesterase"

Listar por tema "acetylcholinesterase"

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