Browsing by Subject "ABC transporter"

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Ensartinib (X-396) Effectively Modulates Pharmacokinetic Resistance Mediated by ABCB1 and ABCG2 Drug Efflux Transporters and CYP3A4 Biotransformation Enzyme

Vagiannis, Dimitrios; Novotna, Eva; Skarka, Adam; Kammerer, Sarah; Kupper, Jan-Heiner; Chen, Si; Guo, Lei; Staud, Frantisek; Hofman, Jakub (MDPI, 2020)

Ensartinib (X-396) is a promising tyrosine kinase inhibitor currently undergoing advanced clinical evaluation for the treatment of non-small cell lung cancer. In this work, we investigate possible interactions of this ...
Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo

Vagiannis, Dimitrios; Budagaga, Youssif; Morell, Anselm; Zhang, Yu; Novotna, Eva; Skarka, Adam; Kammerer, Sarah; Kupper, Jan-Heiner; Hanke, Ivo; Rozkos, Tomas; Hofman, Jakub (MDPI, 2021)

Tepotinib is a novel tyrosine kinase inhibitor recently approved for the treatment of non-small cell lung cancer (NSCLC). In this study, we evaluated the tepotinib's potential to perpetrate pharmacokinetic drug interactions ...

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