Browsing by Subject "ABAD"

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Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17 beta-HSD10 with Implications to Alzheimer's Disease Treatment

Schmidt, Monika; Benek, Ondřej; Vinklářová, Lucie; Hrabinova, Martina; Zemanová, Lucie; Chribek, Matej; Kralova, Vendula; Hroch, Lukas; Doležal, Rafael; Lyčka, Antonín; Prchal, Lukas; Jun, Daniel; Aitken, Laura; Gunn-Moore, Frank; Kuča, Kamil; Musílek, Kamil (MDPI-Molecular diversity preservation international, 2020)

Human 17 beta-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological ...
Frentizole derivatives with mTOR inhibiting and senomorphic properties

Chrienová, Žofia; Rysanek, D.; Novak, J.; Vasicova, P.; Olekšák, Patrik; Andrýs, Rudolf; Skarka, Adam; Dumanovic, J.; Milovanovic, Z.; Jacevic, V.; Chvojkova, M.; Holubova, K.; Valeš, Karel; Skoupilová, Veronika; Valko, M.; Jomova, K.; Alomar, S.Y.; Botelho, F.D.; Costa Franca, Tanos Celmar; Kuča, Kamil; Hodny, Z.; Nepovimová, Eugenie (Elsevier Masson s.r.l., 2023)

Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in ...

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