Browsing by Author "Aitken, Laura"

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  • Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17 beta-HSD10 with Implications to Alzheimer's Disease Treatment 
    Schmidt, Monika; Benek, Ondřej; Vinklářová, Lucie; Hrabinova, Martina; Zemanová, Lucie; Chribek, Matej; Kralova, Vendula; Hroch, Lukas; Doležal, Rafael; Lyčka, Antonín; Prchal, Lukas; Jun, Daniel; Aitken, Laura; Gunn-Moore, Frank; Kuča, Kamil; Musílek, Kamil (MDPI-Molecular diversity preservation international, 2020)
    Human 17 beta-hydroxysteroid dehydrogenase type 10 is a multifunctional protein involved in many enzymatic and structural processes within mitochondria. This enzyme was suggested to be involved in several neurological ...
  • Development of submicromolar 17 beta-HSD10 inhibitors and their in vitro and in vivo evaluation 
    Benek, Ondřej; Vašková, Michaela; Sedláček Miškeříková, Markéta; Schmidt, Monika; Andrýs, Rudolf; Rotterová, Aneta; Skarka, Adam; Hatlapatkova, Jana; Karasova, Jana Zdarova; Medvecký, Matej; Hroch, Lukas; Vinklářová, Lucie; Fisar, Zdenek; Hroudova, Jana; Handl, Jiri; Capek, Jan; Rousar, Tomas; Kobrlova, Tereza; Dolezal, Rafael; Soukup, Ondrej; Aitken, Laura; Gunn-Moore, Frank; Musílek, Kamil (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2023)
    17 beta-hydroxysteroid dehydrogenase type 10 (17 beta-HSD10) is a multifunctional mitochondrial enzyme and putative drug target for the treatment of various pathologies including Alzheimer's disease or some types of ...
  • Novel Benzothiazole-Based Ureas as 17 beta-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment 
    Aitken, Laura; Benek, Ondřej; McKelvie, Brogan E.; Hughes, Rebecca E.; Hroch, Lukas; Schmidt, Monika; Major, Louise L.; Vinklářová, Lucie; Kuča, Kamil; Smith, Terry K.; Musílek, Kamil; Gunn-Moore, Frank J. (MDPI-Molecular diversity preservation international, 2019)
    It has long been established that mitochondrial dysfunction in Alzheimer's disease (AD) patients can trigger pathological changes in cell metabolism by altering metabolic enzymes such as the mitochondrial 17 ...

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