Browsing by Author "Adam, Vojtěch"

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  • Wu, Qinghua; You, Li; Nepovimová, Eugenie; Heger, Zbyněk; Wu, Wenda; Kuča, Kamil; Adam, Vojtěch (BMC, 2022)
    Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby reducing tumoral immunogenicity. Studies have ...
  • Huang, Xueqin; Nepovimová, Eugenie; Adam, Vojtěch; Sivak, Ladislav; Heger, Zbyněk; Valko, Marian; Wu, Qinghua; Kuča, Kamil (BMC, 2024)
    Neutrophils play a Janus-faced role in the complex landscape of cancer pathogenesis and immunotherapy. As immune defense cells, neutrophils release toxic substances, including reactive oxygen species and matrix ...
  • Zuo, Runan; Guo, Xinyi; Song, Xinhao; Gao, Xiuge; Zhang, Junren; Jiang, Shanxiang; Adam, Vojtěch; Kuča, Kamil; Wu, Wenda; Guo, Dawei (Elsevier, 2025)
    The small-molecule alkaloid halofuginone (HF) is obtained from febrifugine. Recent studies on HF have aroused widespread attention owing to its universal range of noteworthy biological activities and therapeutic functions, ...
  • Wang, Yating; Kuča, Kamil; You, Li; Nepovimová, Eugenie; Heger, Zbyněk; Valko, Marian; Adam, Vojtěch; Wu, Qinghua; Jomova, Klaudia (Springer, 2024)
    Increasing evidence has revealed that cellular senescence drives NDs, including Alzheimer’s disease (AD) and Parkinson’s disease. Different senescent cell populations secrete senescence-associated secretory phenotypes ...

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